Basic Information
VIS ID
TVIS10014530
Fusion event
HBV-CCDC191 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
977
Orient
+
Integrated sequence
TATGGGTTATGTCATTGGATGTTATGGGTCCTTGCCACAAGAACACATCATACAAAAAATCAAAGAATGTTTTAGAAAACTTCCTATTAACAGGCCTATT| |GATTGGAAAGTATGTCAACGAATTGTGGGTCTTTTGGGTTTTGCTGCCCCTTTTACACAATGTGGTTATCCTGCGTTGATGCCTTTGTATGCATGTATTC
Host Sequence
Chromosome
chr3
Cytoband
q13.31
Reference genome
GRCh37/hg19
Start
113693582/113974735 (Hg38)
End
113693582/113974735 (Hg38)
Orient
+
Location type
Intronic
Target gene
CCDC191
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-let-7g/Upstream/379793; hsa-mir-12124/Downstream/341740;
Nearest TSS
ENST00000440867/Upstream/16281; ENST00000488665/Downstream/27036;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/26192, chr3-CpG: 35/Downstream/81565
Upstream sequence
AGGACCCTCTTGTATTTAAGGTGAAGCAGAAAACATATTTTCATGCTTTACAGGACACCAAATTGATTAAAGTCGTATTTTAGCATTATCATCCCAGAAA
Downstream sequence
attgtttgtaatttacctgtttaatttcttttttgttctcctgctatgtggctgcctcctttttggcactagatggtgctttaatccctggttcatcttg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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