Basic Information
VIS ID
TVIS10014531
Fusion event
HBV-LOC105374138 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
422
Orient
+
Integrated sequence
CAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCT| |ATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGG
Host Sequence
Chromosome
chr3
Cytoband
q23
Reference genome
GRCh37/hg19
Start
142810702/143091860 (Hg38)
End
142810702/143091860 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105374138
Nearest miRNA
hsa-let-7g/Upstream/8653954; hsa-mir-1224/Downstream/8474016;
Nearest TSS
ENST00000440867/Upstream/54981; ENST00000492307/Downstream/19942;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/89943, chr3-CpG: 317/Downstream/27183
Nearby gene
U2SURP(-31135) ; CHST2(+27916) ;
Upstream sequence
acacacacacacacgcacaaaggaataaaaaacctccacttggataaatttccatatgatgtttctatatctgcacatattattttcatagcaaagattc
Downstream sequence
gaggcaggaggatcgcttgaggccaggagttcaagaccagtgtgggcaacagagtgagacctcatttctacaaaaaatttaaaaaattactcaggtttgg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate