Basic Information
VIS ID
TVIS10014533
Fusion event
HBV-EGFEM1P integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1731
Orient
+
Integrated sequence
ACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGA| |CTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACC
Host Sequence
Chromosome
chr3
Cytoband
q26.2
Reference genome
GRCh37/hg19
Start
168390147/168672359 (Hg38)
End
168390147/168672359 (Hg38)
Orient
-
Location type
ncRNA_intronic
Target gene
EGFEM1P
Nearest miRNA
hsa-let-7g/Upstream/120410; hsa-mir-1224/Downstream/1750744;
Nearest TSS
ENST00000440867/Upstream/383806; ENST00000484765/Downstream/231007;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/422017, chr3-CpG: 39/Downstream/473883
Upstream sequence
AGCAGCAGATTACCAGGCAAAACCAAGAAACATCAATAGATAGGAGTGTAAGACACTGTGTAGCCCTGCACTTCTCTGAAACAGCAGATcagatttccca
Downstream sequence
caaagtgctggcattacagacgtgagcaatcacacctggccTGCTTCCTTTCATTTCTTTTTCCATCACTCACTGCACACTCACATAAAATCTACACAAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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