NAALADL2 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10014534
Fusion event
HBV-NAALADL2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2044
Orient
+
Integrated sequence
TTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATT| |GTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTC
Host Sequence
Chromosome
chr3
Cytoband
q26.31
Reference genome
GRCh37/hg19
Start
175122471/175404682 (Hg38)
End
175122471/175404682 (Hg38)
Orient
+
Location type
Intronic
Target gene
NAALADL2
Nearest miRNA
hsa-let-7g/Upstream/35061; hsa-mir-1224/Downstream/1110421;
Nearest TSS
ENST00000440867/Upstream/133586; ENST00000617758/Downstream/371651;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/963124, chr3-CpG: 133/Downstream/1791767
Upstream sequence
AAATGAAAATTCAAACTAACATATCATTTATTCAAGATTCTCTACAACTGGAAATACCAATCTATCTTTCTAGTCTTATTTTCAAAGAATTGCTTCTACC
Downstream sequence
CCTTTTTCCCTGCTTTTGTAAACTGCTGAGAATATCTATGGTTACAGTTCTAAATGGAATTTCATTAAAGCTGCATCTGAACCATGTACAAGTTGACCTC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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