VISDB Viral Integration Site DataBase

VIS ID

TVIS10014536

Fusion event

HBV-RBMS3 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

2019

Orient

+

Integrated sequence

TAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGG| |GAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGG

Chromosome

chr3

Cytoband

p24.1

Reference genome

Start

End

29560931/29519440 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-30a-5p ; hsa-mir-16-5p ; hsa-mir-578 ; hsa-mir-526b-5p ; hsa-mir-3190-3p ; hsa-mir-6077 ; hsa-mir-7-5p ; hsa-mir-4282 ; hsa-mir-3674 ; hsa-mir-1238-3p ; hsa-mir-670-3p ; hsa-mir-5706 ; hsa-mir-4782-5p ; hsa-mir-516b-5p ; hsa-mir-1299 ; hsa-mir-6881-3p ; hsa-mir-6780a-3p ; hsa-mir-7111-3p ; hsa-mir-4703-3p ; hsa-mir-5093 ; hsa-mir-3182 ; hsa-mir-6128 ; hsa-mir-875-3p ; hsa-mir-877-3p ; hsa-mir-1324

Nearest miRNA

hsa-mir-12127/Upstream/3854501; hsa-let-7g/Downstream/1642264;

Nearest TSS

Nearest CpG islands

None/Target, chr3-CpG: 148/Upstream/942961, chr3-CpG: 88/Downstream/1087055

Nearest cancer related gene

RBMS3(TSG, No orient, 0)

Upstream sequence

ggcggatcacaaggtcaggagatcaagaccaccctggctaacacggtgaaaccccTCGATGATAGTTccattcgattctatgcgatgattccattccatt

Downstream sequence

ATTGAGAAACAAAATATAAAAGGAGCAAAAAATAGAAAGGTCACAAACATTTTGCTTTTGAAAACAGTCTGAAAACCACTCAGTCCTATGCCATTCTCCT