Basic Information
VIS ID
TVIS10014537
Fusion event
HBV-LINC00971 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2331
Orient
+
Integrated sequence
TGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTT| |CCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTC
Host Sequence
Chromosome
chr3
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
84875957/84826806 (Hg38)
End
84875957/84826806 (Hg38)
Orient
+
Location type
ncRNA_intronic
Target gene
LINC00971
Nearest miRNA
hsa-let-7g/Upstream/5318837; hsa-mir-12124/Downstream/558904;
Nearest TSS
ENST00000440867/Upstream/2840654; ENST00000488348/Downstream/42769;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/2018713, chr3-CpG: 48/Downstream/132327
Upstream sequence
acagttctgtcctaaatcgggtgttcagaaagtttttctctttgatcaaggttaccagtgccctaagaagttttcagtccaaaattgtcttctatacttt
Downstream sequence
TATTTTAATCATTTTTAAATAGTTTTTTTTTCCTTCCGTGGCTTAACATATTCCCAAGAAGTAATGACACAGAAAAAATAGGGATCCCTATAAAGCTGAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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