Basic Information
VIS ID
TVIS10014539
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
1373
Orient
+
Integrated sequence
TGCGGAACTCCTAGCCGCTTGTTTTGCTCGCAGCAGGTCTGGAGCAAACATTATCGGGACTGATAACTCTGTTGTCCTATCCCGCAAATATACATCGTTT| |CCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCCTGCGGACGACCCTTCTCGGGGTC
Host Sequence
Chromosome
chr4
Cytoband
q26
Reference genome
GRCh37/hg19
Start
119296313/118375158 (Hg38)
End
119296313/118375158 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/3718304; hsa-mir-1305/Downstream/7132101;
Nearest TSS
ENST00000502981/Upstream/22155; ENST00000508801/Downstream/309308;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/21855, chr4-CpG: 28/Downstream/310164
Nearby gene
PRSS12(-22391) ; CEP170P1(+141182) ;
Upstream sequence
ggcaaagagcatatggaatgggtagttgaagcagatagttgtaaatactagctatgatgcagatagttgtaaatactagctatgactacttgtccagttg
Downstream sequence
agccatgtggaactgcgagtcaattaaatgtctttcattgtttttttttttttattttttttttttttatttttttttttttttgagacggagtctcgct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate