Basic Information
VIS ID
TVIS10014541
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2324
Orient
+
Integrated sequence
TCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATC| |AACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGA
Host Sequence
Chromosome
chr4
Cytoband
q34.2
Reference genome
GRCh37/hg19
Start
177124185/176203034 (Hg38)
End
177124185/176203034 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/1779170; hsa-mir-1305/Downstream/5966259;
Nearest TSS
ENST00000502981/Upstream/7363; ENST00000513139/Downstream/34540;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/7292, chr4-CpG: 111/Downstream/116750
Nearby gene
SPATA4(-7363) ; ASB5(+10641) ;
Nearest cancer related gene
SPATA4(OG, -7363) ;
Upstream sequence
cttgagaaagaagctcaatgagtgagaactgccttctaagataccaaACCATGCTAACATAttaggctgaatcatatgaaaccagatattcaatgacttg
Downstream sequence
GTGATTAGAAACCTCTTTTTAAAAGGGGGGGGGCTCATCCTTTTGGATGTGCAGCGTGTGAGGAGATAAGAAAAACTTCCTTTAGCTTTTCCTTGAAAAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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