Basic Information
VIS ID
TVIS10014542
Fusion event
HBV-LOC100129245 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
697
Orient
+
Integrated sequence
ACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTC| |AGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAGCATCTTGAGTCCCTTTTTACC
Host Sequence
Chromosome
chr4
Cytoband
q35.1
Reference genome
GRCh37/hg19
Start
185480349/184559195 (Hg38)
End
185480349/184559195 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC100129245
Nearest miRNA
hsa-mir-12113/Upstream/2389817; hsa-mir-3945/Downstream/291818;
Nearest TSS
ENST00000502981/Upstream/21641; ENST00000509538/Downstream/65684;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/84168, chr4-CpG: 110/Downstream/89612
Nearby gene
IRF2(-84623) ; CASP3(+68501) ;
Upstream sequence
GAGAACCTTTACCTCCATTTCCCTAAGGTATGTGTGAATATCCTCATGGTAGTCTGGTACTTCATTAACACTCACTGGCTTTTCATCTTCTAATATAATT
Downstream sequence
ACCACCACCTCCTCTTCCACCTCTAAAACCACCGCTTCTGCCACTGCCTCTGCCACCTCCCCTTCTTCCTCCTCGGCCTCCCCTGCCACCACATCTTGGA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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