Basic Information
VIS ID
TVIS10014544
Fusion event
HBV-LOC101928622 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1389
Orient
+
Integrated sequence
GCTTGTTTTGCTCGCAGCAGGTCTGGAGCAAACATTATCGGGACTGATAACTCTGTTGTCCTATCCCGCAAATATACATCGTTTCCATGGCTGCTAGGCT| |GTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCCTGCGGACGACCCTTCTCGGGGTCGCTTGGGACTCTCTCG
Host Sequence
Chromosome
chr4
Cytoband
p15.1
Reference genome
GRCh37/hg19
Start
33909156/33907534 (Hg38)
End
33909156/33907534 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA4D
Target gene
LOC101928622
Nearest miRNA
hsa-mir-12113/Upstream/5087866; hsa-mir-1243/Downstream/2518832;
Nearest TSS
ENST00000502981/Upstream/18566; ENST00000514737/Downstream/132348;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/3184314, chr4-CpG: 100/Downstream/2336475
Upstream sequence
GTAGGTTAGCCTAAGAATATAGTTAGTTGAGGTTGGTGAAAATTGACACTTCATTACGGTTCATGTCAGGACGTCAGAGGAAAAGGACGTGGACCGAGTG
Downstream sequence
aattctgaacaaactaagaaaagaggagaactccttacaaattggttgaagacatctcttaaaaaacagaaacaaaaaaaaaaaaaccctacagctaata
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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