Basic Information
VIS ID
TVIS10014548
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2129
Orient
+
Integrated sequence
AGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTT| |GGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACT
Host Sequence
Chromosome
chr5
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
113188043/113852346 (Hg38)
End
113188043/113852346 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10397/Upstream/3338431; hsa-mir-103a-1/Downstream/2403397;
Nearest TSS
ENST00000502646/Upstream/261188; ENST00000512927/Downstream/203660;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/338061, chr5-CpG: 76/Downstream/203028
Nearby gene
YTHDC2(-257059) ; KCNN2(+509973) ;
Upstream sequence
CTAAAGGCAACGATGCTGGCAGGCAACCAGCTCTCGGCGTGGACTGACACTTCAGCTACTCTGGGAAAAGCAACCTCATTCAAACAAGCCAGAGCCTTAG
Downstream sequence
ATACATGGTATAATACTTTTTAGTACAATATTTTttatactcagccaagttgtcatttatgtagaaatgaaacagaaagacattcttgtatatgctaaga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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