Basic Information
VIS ID
TVIS10014553
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1968
Orient
+
Integrated sequence
AGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGAC| |TTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCA
Host Sequence
Chromosome
chr5
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
81075518/81779699 (Hg38)
End
81075518/81779699 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10397/Upstream/8901036; hsa-mir-103a-1/Downstream/1060456;
Nearest TSS
ENST00000502646/Upstream/27902; ENST00000512859/Downstream/71902;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/27669, chr5-CpG: 85/Downstream/192059
Nearby gene
SSBP2(-28446) ; ATG10(+192326) ;
Nearest cancer related gene
SSBP2(TSG, -28446) ;
Upstream sequence
aggagttgcatcactttacatttcgactagtagtgtgaaaatgttccaatttctccacattctcaccaatacttactgtatttttgattctagccatcct
Downstream sequence
GAAGGAAAAAGGCACATGGGATATGTCTAGGAAAAAAGGTTTTCAAGATTTAGAGAAGAGAGTTCTTGAAAAGCTATAGGAAGTCAAGAGGGGTAGAAAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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