VISDB Viral Integration Site DataBase

VIS ID

TVIS10014554

Fusion event

HBV-SEMA5A integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

2090

Orient

+

Integrated sequence

TTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGG| |GGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAG

Chromosome

chr5

Cytoband

p15.31

Reference genome

Start

End

9419343/9419231 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-21-5p ; hsa-mir-218-5p ; hsa-mir-6811-5p ; hsa-mir-6511b-5p ; hsa-mir-6722-3p ; hsa-mir-1909-3p ; hsa-mir-6836-5p ; hsa-mir-6132 ; hsa-mir-6754-5p ; hsa-mir-4441 ; hsa-mir-100-3p ; hsa-mir-4270 ; hsa-mir-4709-3p ; hsa-mir-4645-3p ; hsa-mir-3185 ; hsa-mir-144-3p ; hsa-mir-8077 ; hsa-mir-496 ; hsa-mir-216a-5p ; hsa-mir-548c-3p ; hsa-mir-4695-3p ; hsa-mir-4772-3p ; hsa-mir-6787-3p ; hsa-mir-1304-3p ; hsa-mir-660-3p ; hsa-mir-6736-3p ; hsa-mir-6890-3p ; hsa-mir-4714-3p

Nearest miRNA

hsa-mir-4277/Upstream/365336; hsa-mir-10397/Downstream/983133;

Nearest TSS

Nearest CpG islands

None/Target, chr5-CpG: 87/Upstream/961071, chr5-CpG: 138/Downstream/125349

Upstream sequence

TGAGGTCGGCAAACACTGAAATGCTAACAAACGCAACCTTAAATGTAACCTTTCCTACTTTCAGAAACTGCCGGAGGAAATTGCTTTATTTATGGAGCTA

Downstream sequence

tccttggtatgatttccaggtttttgaatttattgaggcttgctttgtgaccaagcatgtggtcgatcttagaagacagtctgtgtgcagatgagaaaaa