VISDB Viral Integration Site DataBase

VIS ID

TVIS10014556

Fusion event

HBV-TRERF1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|large S protein|

Start

3073

Orient

+

Integrated sequence

CAGACGCCAACAAGGTAGGAGCTGGAGCATTCGGGCTGGGTTTCACCCCACCGCACGGAGGCCTTTTGGGGTGGAGCCCTCAGGCTCAGGGCATACTACA| |AACTTTGCCAGCAAATCCGCCTCCTGCCTCCACCAATCGCCAGTCAGGAAGGCAGCCTACCCCGCTGTCTCCACCTTTGAGAAACACTCATCCTCAGGCC

Chromosome

chr6

Cytoband

p21.1

Reference genome

Start

End

42384631/42416893 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-30b-5p ; hsa-mir-101-3p ; hsa-mir-324-5p ; hsa-mir-342-3p ; hsa-mir-377-3p ; hsa-mir-3120-3p ; hsa-mir-603 ; hsa-mir-8485

Nearest miRNA

hsa-mir-10398/Upstream/683283; hsa-mir-10524/Downstream/1017649;

Nearest TSS

Nearest CpG islands

None/Target, chr6-CpG: 120/Upstream/157143, chr6-CpG: 18/Downstream/34879

Upstream sequence

AAAAAGAAGAAACAATTTCAAAGGCTGTATTTAAAACCTACACACGAATGAGTAATTTATATGCATTTATCATGCAAGTATACGATCCCCAGGGTGGAAA

Downstream sequence

ttgtgtgtgttttttttaagaacacatactttcatgttatataaACTATTTCTAAACATAGAAAAAGATCCTACCAGCATCACTATAAGAAGTAAATATA