Basic Information
VIS ID
TVIS10014559
Fusion event
HBV-LOC105375153 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1386
Orient
+
Integrated sequence
GCCGCTTGTTTTGCTCGCAGCAGGTCTGGAGCAAACATTATCGGGACTGATAACTCTGTTGTCCTATCCCGCAAATATACATCGTTTCCATGGCTGCTAG| |GCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCCTGCGGACGACCCTTCTCGGGGTCGCTTGGGACTCTC
Host Sequence
Chromosome
chr7
Cytoband
p21.3
Reference genome
GRCh37/hg19
Start
11377966/11338339 (Hg38)
End
11377966/11338339 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105375153
Nearest miRNA
hsa-mir-339/Upstream/4271294; hsa-mir-10399/Downstream/6788881;
Nearest TSS
ENST00000635602/Upstream/227358; ENST00000425837/Downstream/41416;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/364078, chr7-CpG: 25/Downstream/493442
Nearby gene
THSD7A(+32096) ;
Upstream sequence
CTTAAAATATAAAGCCACTTTTCCAAATTTGTAAACCTAGCTTGAGAAATGTAAGTATTGGaaaaaatattttatattattaCTGAATTTTTGTGTATTT
Downstream sequence
TAAGGAATAGAGAAAACAATGCCAGTTgagagagaagcaggggcggggggagaggggtggggaggagagagggagagagagagAATGAATATGATTGAAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate