Basic Information
VIS ID
TVIS10014561
Fusion event
HBV-chr7 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
1171
Orient
+
Integrated sequence
GTATTCAATCTAAGCAGGCTTTCACTTTCTCGCCAACTTACAAGGCCTTTCTGTGTAAACAATACCTGAACCTTTACCCCGTTGCCCGGCAACGGCCAGG| |TCTGTGCCAAGTGTTTGCTGACGCAACCCCCACTGGCTGGGGCTTGGTCATGGGCCATCAGCGCATGCGTGGAACCTTTTCGGCTCCTCTGCCGATCCAT
Host Sequence
Chromosome
chr7
Cytoband
q35
Reference genome
GRCh37/hg19
Start
143500006/143802913 (Hg38)
End
143500006/143802913 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10399/Upstream/420113; hsa-mir-153-2/Downstream/3575104;
Nearest TSS
ENST00000635602/Upstream/45217; ENST00000408955/Downstream/79970;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/181942, chr7-CpG: 72/Downstream/33775
Nearby gene
CTAGE6(-45163) ; LOC154761(+9055) ;
Upstream sequence
GGCCTAGGCTGCCCAAGGCTAGGTCTGGCCGGGTGTTTGGAGCACCCGCAGGCCCCCCGAGGAGGGAGGCGCCCTGAGCAGGTGTCTGCTCCTTGGACGT
Downstream sequence
AACAAGTTTCCATAAATGAAGTATTACTTCATTTAGGAAACTGATTATGTGACTGCAAGTAGATCAAAAATATTGTCTGCATCCCTATATTGCCCAGCCT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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