Basic Information
VIS ID
TVIS10014565
Fusion event
HBV-chr8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
408
Orient
-
Integrated sequence
AAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTC| |TTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCA
Host Sequence
Chromosome
chr8
Cytoband
q24.21
Reference genome
GRCh37/hg19
Start
127409999/126397754 (Hg38)
End
127409999/126397754 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA8C ; FRA8E
Nearest miRNA
hsa-mir-12123/Upstream/1575696; hsa-mir-10400/Downstream/1398208;
Nearest TSS
ENST00000518652/Upstream/72259; ENST00000520171/Downstream/76435;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/965556, chr8-CpG: 180/Downstream/158677
Nearby gene
LINC00861(-446558) ; LRATD2(+154684) ;
Upstream sequence
GTTATTGCATGTAATTGTTAAGTAAGGTACAAGCACAGAAATCAACTGCTATTCAAGGAATTATAAAGTAACTTTATAAGCCTTATATAAATAAGCCTAG
Downstream sequence
agagacgggatttcagcatgttgcccaggctggtctcaaactcctgggctcaagaaatccacatgcctcagcctctcaaagtgctgggattacaggcgtc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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