Basic Information
VIS ID
TVIS10014567
Fusion event
HBV-LOC105375821 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
747
Orient
+
Integrated sequence
GTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATG| |ATGTGGTATTGGGGGCCAAGTCTGTACAGCATCTTGAGTCCCTTTTTACCGCTGTTACCAATTTTCTTTTGTCTTTGGGTATACATTTAAACCCTAACAA
Host Sequence
Chromosome
chr8
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
49307858/48395298 (Hg38)
End
49307858/48395298 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105375821
Nearest miRNA
hsa-mir-124-1/Upstream/5499023; hsa-mir-10400/Downstream/13319490;
Nearest TSS
ENST00000518652/Upstream/345718; ENST00000430626/Downstream/121791;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/14311, chr8-CpG: 32/Downstream/1205
Nearby gene
UBE2V2(-333404) ; EFCAB1(+319616) ;
Upstream sequence
ATTTATACTGCCCTCCCCCTCTCCCTGAGATTCTCTCACAAGGCTGAGCTCTAGTCAGTGAATAGTAACCATGTCAGAGGAGGAGGCTGAACATACTGTC
Downstream sequence
CTTTCTATTTCAGTCTTCAGAAGCTGATACTTTGGCTCAGTAAAGCCAGGATTGTGTGCTCACTAAGGTGTCTTTAGGGTGGCTATCTCACAGAGCCCGA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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