KLF4 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10014570
Fusion event
HBV-KLF4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
X protein|
Start
1799
Orient
-
Integrated sequence
GAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGG| |TCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGG
Host Sequence
Chromosome
chr9
Cytoband
q31.2
Reference genome
End
110252240/107489959 (Hg38)
Orient
+
Location type
upstream
Target gene
Nearest miRNA
hsa-let-7a-1/Upstream/888937; hsa-mir-12126/Downstream/1556270;
Nearest CpG islands
chr9-CpG: 291/Target, None/Upstream, None/Downstream
Nearest cancer related gene
KLF4(TSG, No orient, 0)
Upstream sequence
TTGGCTGCAGGTTATCTGCGGACATCCCTGTTTGCACATCACGGGAGTCTAGATTGTAAGACCCCTCCTCATACTCTAAAACTTCCTCTGGTTCCTCGGT
Downstream sequence
ggctgggccgggcCGTGACGCCAGCCAGGCAGCTGGCGGGCTGGAGCCGAGCTGACGCcggcggcagtggtgtcggcggcggcggcggcgTCCGCCCCAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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