VISDB Viral Integration Site DataBase

VIS ID

TVIS10014570

Fusion event

HBV-KLF4 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1799

Orient

-

Integrated sequence

GAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGG| |TCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGG

Chromosome

chr9

Cytoband

q31.2

Reference genome

Start

End

110252240/107489959 (Hg38)

Orient

+

Location type

upstream

Target gene

miRNAs that regulate target gene

hsa-mir-145-5p ; hsa-mir-10b-5p ; hsa-mir-25-3p ; hsa-mir-135b-5p ; hsa-mir-130a-3p ; hsa-mir-663a ; hsa-mir-103a-3p ; hsa-mir-107 ; hsa-mir-335-5p ; hsa-mir-128-3p ; hsa-mir-124-3p ; hsa-mir-30b-5p ; hsa-mir-29a-3p ; hsa-mir-15a-5p ; hsa-mir-624-3p ; hsa-mir-34a-5p ; hsa-mir-7-5p ; hsa-mir-137 ; hsa-mir-152-3p ; hsa-mir-206 ; hsa-mir-32-5p ; hsa-mir-367-3p ; hsa-mir-92a-3p ; hsa-mir-135a-5p ; hsa-mir-29c-3p ; hsa-mir-375

Nearest miRNA

hsa-let-7a-1/Upstream/888937; hsa-mir-12126/Downstream/1556270;

Nearest TSS

Nearest CpG islands

chr9-CpG: 291/Target, None/Upstream, None/Downstream

Nearest cancer related gene

KLF4(OG, No orient, 0)

Upstream sequence

TTGGCTGCAGGTTATCTGCGGACATCCCTGTTTGCACATCACGGGAGTCTAGATTGTAAGACCCCTCCTCATACTCTAAAACTTCCTCTGGTTCCTCGGT

Downstream sequence

ggctgggccgggcCGTGACGCCAGCCAGGCAGCTGGCGGGCTGGAGCCGAGCTGACGCcggcggcagtggtgtcggcggcggcggcggcgTCCGCCCCAG