VISDB Viral Integration Site DataBase

VIS ID

TVIS10014571

Fusion event

HBV-ASTN2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

363

Orient

-

Integrated sequence

GACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGT| |CCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTA

Chromosome

chr9

Cytoband

q33.1

Reference genome

Start

End

119608077/116845798 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

FRA9E ; FRA9B

Target gene

miRNAs that regulate target gene

hsa-mir-26b-5p ; hsa-mir-526b-5p ; hsa-mir-1253 ; hsa-mir-591 ; hsa-mir-6761-5p ; hsa-mir-5571-5p ; hsa-mir-6880-5p ; hsa-mir-8085 ; hsa-mir-6746-5p ; hsa-mir-6731-5p ; hsa-mir-6797-5p ; hsa-mir-1249-5p ; hsa-mir-765 ; hsa-mir-6077 ; hsa-mir-766-5p ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-6760-5p ; hsa-mir-4419a ; hsa-mir-4779 ; hsa-mir-6891-5p ; hsa-mir-3173-3p ; hsa-mir-5703 ; hsa-mir-4516 ; hsa-mir-4434 ; hsa-mir-4784 ; hsa-mir-3150b-3p ; hsa-mir-6770-5p ; hsa-mir-124-5p ; hsa-mir-6867-5p ; hsa-mir-5195-5p ; hsa-mir-8485 ; hsa-mir-5010-3p ; hsa-mir-2113 ; hsa-mir-6738-3p ; hsa-mir-544a ; hsa-mir-6071 ; hsa-mir-6828-3p ; hsa-mir-3152-3p ; hsa-mir-1251-3p

Nearest miRNA

hsa-let-7a-1/Upstream/2636269; hsa-mir-12126/Downstream/3399181;

Nearest TSS

Nearest CpG islands

None/Target, chr9-CpG: 64/Upstream/158310, chr9-CpG: 163/Downstream/567177

Upstream sequence

agaagaatggcatgaacccgggaggtggagcttgcagtgagccgagaccgcaccactgcactccagcctgggcgacaaagctggactccgtctcaaaaac

Downstream sequence

gaaaaacagtatggaggttcctcaagaaattaaaaatagaactaccatatgatctagcaattgcacttctggatatatatccaaaagccctgaaaataaa