Basic Information
VIS ID
TVIS10014574
Fusion event
HBV-LOC107987068 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1978
Orient
-
Integrated sequence
CTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTT| |CAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAAT
Host Sequence
Chromosome
chr9
Cytoband
q13
Reference genome
GRCh37/hg19
Start
69750819/64738401 (Hg38)
End
69750819/64738401 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA9F
Target gene
LOC107987068
Nearest miRNA
hsa-mir-101-2/Upstream/23504566; hsa-let-7a-1/Downstream/6071574;
Nearest TSS
ENST00000422679/Upstream/368806; ENST00000464913/Downstream/27134;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/249594, chr9-CpG: 309/Downstream/34455
Nearby gene
LOC100133920(-85870) ; FOXD4L5(+424888) ;
Upstream sequence
GGCTCGGGGCGGAGGCTGTGGAATGGCCGGGAATGCGCTCCGGCCGGGCAGCGGCTTCGCTCGGTAGCTGCCGTATCTCCGGGCCGTGCCCAGTGCTTAG
Downstream sequence
aaaggaaggaaggaagTTTACAGAGTTTTTTGAGGTGTTAGTGTTCCCTAAATTGTATGGTCTTCAGAGGTTTAccctcctatagcttcaaggggtgagt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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