VISDB Viral Integration Site DataBase

VIS ID

TVIS10014575

Fusion event

HBV-APBA1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

325

Orient

+

Integrated sequence

AGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAA| |CCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATG

Chromosome

chr9

Cytoband

q21.12

Reference genome

Start

End

72147720/69532804 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-450a-1-3p ; hsa-mir-7977 ; hsa-mir-8059 ; hsa-mir-4471 ; hsa-mir-1292-5p ; hsa-mir-6774-5p ; hsa-mir-635 ; hsa-mir-3667-3p ; hsa-mir-6734-3p ; hsa-mir-4667-3p ; hsa-mir-1470 ; hsa-mir-2114-5p ; hsa-mir-212-3p ; hsa-mir-132-3p ; hsa-mir-3199 ; hsa-mir-365a-5p ; hsa-mir-365b-5p ; hsa-mir-574-5p ; hsa-mir-6818-5p ; hsa-mir-6867-5p ; hsa-mir-8052 ; hsa-mir-892a

Nearest miRNA

hsa-mir-101-2/Upstream/28298969; hsa-let-7a-1/Downstream/1277171;

Nearest TSS

Nearest CpG islands

None/Target, chr9-CpG: 64/Upstream/15546, chr9-CpG: 123/Downstream/139084

Upstream sequence

GCGCCCTCGGGAGACGGGCCCTGTCGGGTGTCGAGACGCGAACACGACCCAATGCCAAGAACGGGCGGTGAAGATGAACGGAAAAGCCCCAAGCAGCGGC

Downstream sequence

ATTTGCAATCATTAATTCTTACAACCTTTCTTCCATCTATAaaattggtccatgaagggtaatttgaaagtatccatcaaaattaccactcagaggaatt