Basic Information
VIS ID
TVIS10014577
Fusion event
HBV-chr9 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
748
Orient
+
Integrated sequence
TGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGA| |TGTGGTATTGGGGGCCAAGTCTGTACAGCATCTTGAGTCCCTTTTTACCGCTGTTACCAATTTTCTTTTGTCTTTGGGTATACATTTAAACCCTAACAAA
Host Sequence
Chromosome
chr9
Cytoband
q21.32
Reference genome
GRCh37/hg19
Start
84436398/81821483 (Hg38)
End
84436398/81821483 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-101-2/Upstream/11011399; hsa-let-7a-1/Downstream/2148265;
Nearest TSS
ENST00000422679/Upstream/73540; ENST00000419782/Downstream/107031;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/131397, chr9-CpG: 137/Downstream/1240617
Nearby gene
TLE1(-132802) ; SPATA31D5P(+91954) ;
Nearest cancer related gene
TLE1(OG, -132802) ;
Upstream sequence
tttggatagctttgaggatttcgttggaaacgggaatatcttcatataaaatctagacagaagcattctcagaaacatctctgtgatgtttgcattcaag
Downstream sequence
gccatgttggccaggctggtctcaaactcctgacctcaggtgatccacctgacttaccctcccaaagtgttgggattataggcgtgagccactgtgccca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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