Basic Information
VIS ID
TVIS10014581
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
236
Orient
+
Integrated sequence
TTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCAC| |AATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCAC
Host Sequence
Chromosome
chrX
Cytoband
q27.2
Reference genome
GRCh37/hg19
Start
141034984/141947198 (Hg38)
End
141034984/141947198 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRAXD ; FRAXA
Nearest miRNA
hsa-let-7f-2/Upstream/1020967; hsa-mir-105-1/Downstream/4045552;
Nearest TSS
ENST00000429181/Upstream/42396; ENST00000446864/Downstream/258092;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/769978, chrX-CpG: 130/Downstream/1686396
Nearby gene
MAGEC1(-37797) ; MAGEC2(+255144) ;
Upstream sequence
gcatgttctcactcataggtgggaactgaacaatgagaacacatggacacaggaaggggaacatcacacaccggggcctgttgtggggtggggggaggtg
Downstream sequence
attgtgtattcttggcacctttgtcaaaaataaattgacagtaggctgggcatggtgggtcatgcctgtaatcccagcactttgggaggccgaggcgggt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate