Basic Information
VIS ID
TVIS10014582
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1910
Orient
+
Integrated sequence
GCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACAT| |CGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCT
Host Sequence
Chromosome
chrX
Cytoband
p11.3
Reference genome
GRCh37/hg19
Start
45778342/45918907 (Hg38)
End
45778342/45918907 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1587/Upstream/171783; hsa-let-7f-2/Downstream/1668522;
Nearest TSS
ENST00000429181/Upstream/1867; ENST00000464900/Downstream/408738;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/67035, chrX-CpG: 53/Downstream/527907
Nearby gene
MIR222(-171812) ; KRBOX4(+528282) ;
Nearest cancer related gene
MIR222(OG, -171812) ;
Upstream sequence
tgcaggttagttacatatgtatacatgtgccatgttggtatgctgcacccagtaactcgtcatttaacattaggtatatctccaaatgctatccctccca
Downstream sequence
attctcctgcctcagcctcttgagtacctgggactacagccgcccgccaccacgcccggctaattttttgtatttttagtggagacggggtttcaccatg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate