Basic Information
VIS ID
TVIS10014588
Fusion event
HBV-chr12 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1541
Orient
+
Integrated sequence
GCTGAATCCTGCGGACGACCCTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTAC| |GCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATT
Host Sequence
Chromosome
chr12
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
58701383/58307600 (Hg38)
End
58701383/58307600 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1228/Upstream/482908; hsa-let-7i/Downstream/3952759;
Nearest TSS
ENST00000382841/Upstream/219708; ENST00000548969/Downstream/236524;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/371379, chr12-CpG: 100/Downstream/612178
Nearby gene
ATP23(-350331) ; LRIG3(+564554) ;
Nearest cancer related gene
LRIG3(TSG, +564554) ;
Upstream sequence
attgttgagacctactgttcagaaaaaagattcctttcaaaatgttactgctcattgacaatgcacctaagttgcccaacagctctgattgagatataca
Downstream sequence
aggaaattaatgttttcatgcctgctaacacaacatccattctgtagctcatgaactaagaagtaattctgactttcaagtcttattatttaagggatac
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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