Basic Information
VIS ID
TVIS10014589
Fusion event
HBV-LOC107984974 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
577
Orient
+
Integrated sequence
CCTCTAATTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCA| |AACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAG
Host Sequence
Chromosome
chr17
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
29358188/31031170 (Hg38)
End
29358188/31031170 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC107984974
Nearest miRNA
hsa-mir-1180/Upstream/913998; hsa-mir-10226/Downstream/63180;
Nearest TSS
ENST00000595228/Upstream/43093; ENST00000489712/Downstream/63757;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/21736, chr17-CpG: 71/Downstream/63407
Nearby gene
RNF135(-31259) ; MIR4733(+63180) ;
Upstream sequence
GCAACTCTTTATTTTCCTTTTTTTTTAGAGCCCTTCAACCTCTGCCAATATCTTTGTAAAAATATTAAGATTATTACATTTCTATAGTGATTTGCCTCTT
Downstream sequence
TTGCATTAAATGAATTATGATACAGAGTTGATAGAAAGTAGCGGCCTTGCccgggcatggtggctcaggcctgtaatcccagcactttgggaggctgagg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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