VISDB Viral Integration Site DataBase

VIS ID

TVIS10014592

Fusion event

HBV-EPHA4 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

323

Orient

+

Integrated sequence

CAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCC| |AACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTA

Chromosome

chr2

Cytoband

q36.1

Reference genome

Start

End

222290950/221426230 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-10a-5p ; hsa-mir-335-5p ; hsa-mir-130b-3p ; hsa-mir-132-3p ; hsa-mir-93-5p ; hsa-mir-21-5p ; hsa-mir-505-3p ; hsa-mir-361-5p ; hsa-mir-320a ; hsa-mir-10b-5p ; hsa-mir-92a-3p ; hsa-mir-22-5p ; hsa-mir-143-5p ; hsa-mir-548ax ; hsa-mir-548ao-5p ; hsa-mir-4277 ; hsa-mir-5584-3p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-106a-5p ; hsa-mir-526b-3p ; hsa-mir-106b-5p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-5011-3p ; hsa-mir-1255b-5p ; hsa-mir-1255a ; hsa-mir-6744-5p ; hsa-mir-202-3p ; hsa-mir-676-5p ; hsa-mir-4735-5p ; hsa-mir-4275 ; hsa-mir-490-5p ; hsa-mir-5583-5p ; hsa-mir-3129-3p ; hsa-mir-4796-3p ; hsa-mir-548ah-5p ; hsa-mir-7844-5p ; hsa-mir-3609 ; hsa-mir-4500 ; hsa-let-7b-5p ; hsa-let-7c-5p ; hsa-let-7i-5p ; hsa-let-7d-5p ; hsa-mir-4458 ; hsa-let-7f-5p ; hsa-let-7g-5p ; hsa-let-7a-5p ; hsa-let-7e-5p ; hsa-mir-98-5p ; hsa-mir-498 ; hsa-mir-4446-5p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-3180-5p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-623 ; hsa-mir-4436b-5p ; hsa-mir-3124-3p ; hsa-mir-6832-3p ; hsa-mir-4673 ; hsa-mir-4645-5p ; hsa-mir-605-5p ; hsa-mir-592 ; hsa-mir-597-5p ; hsa-mir-3937 ; hsa-mir-4733-3p ; hsa-mir-1911-3p

Nearest miRNA

hsa-mir-10b/Upstream/1519665; hsa-mir-1244-1/Downstream/3584231;

Nearest TSS

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/1798165, chr2-CpG: 260/Downstream/144780

Upstream sequence

CTTGCCAGGTCCCTGTACATAGGGCGACAAAAAAGGGACAGAAGAAGTCACAGGGACTGACAATCTCTTTTCTTGGGCTTCATGCAGACACACGTTTGAA

Downstream sequence

TCAGCCACAATTAATACAGCACAACAAGGCAGGTGTATTAAAATGTTTCATTAAGCAATTTAATGCAAGAATGTAGATACTTTATAGAGGCTGTGTAAAA