Basic Information
VIS ID
TVIS10014600
Fusion event
HBV-chr7 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1431
Orient
+
Integrated sequence
ACTGATAACTCTGTTGTCCTATCCCGCAAATATACATCGTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACG| |TCCCGTCGGCGCTGAATCCTGCGGACGACCCTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCAC
Host Sequence
Chromosome
chr7
Cytoband
p13
Reference genome
GRCh37/hg19
Start
45158228/45118629 (Hg38)
End
45158228/45118629 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA7D
Nearest miRNA
hsa-mir-1183/Upstream/236829; hsa-mir-10399/Downstream/11837156;
Nearest TSS
ENST00000635602/Upstream/6582; ENST00000242249/Downstream/39162;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/6674, chr7-CpG: 59/Downstream/38953
Nearby gene
TBRG4(-6882) ; RAMP3(+39139) ;
Upstream sequence
CTAGACTTTGACTACAACCATGCAACAAAAGAAAAAGATGGGGAGGATAAGGAGGGGAGGGGGAGGAGAGCCTGCATATAAAAAAAGACCCAAAGAGAAG
Downstream sequence
ggcctggagcagaagggctgtccctcattgtctgatacctggccctggagtgattagagcaagtccatagtggccagagtgtgagagccccatagaggag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate