Basic Information
VIS ID
TVIS10014601
Fusion event
HBV-chr7 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
1168
Orient
+
Integrated sequence
CATGTATTCAATCTAAGCAGGCTTTCACTTTCTCGCCAACTTACAAGGCCTTTCTGTGTAAACAATACCTGAACCTTTACCCCGTTGCCCGGCAACGGCC| |AGGTCTGTGCCAAGTGTTTGCTGACGCAACCCCCACTGGCTGGGGCTTGGTCATGGGCCATCAGCGCATGCGTGGAACCTTTTCGGCTCCTCTGCCGATC
Host Sequence
Chromosome
chr7
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
46861075/46821477 (Hg38)
End
46861075/46821477 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1183/Upstream/1939677; hsa-mir-10399/Downstream/10134308;
Nearest TSS
ENST00000635602/Upstream/61626; ENST00000429010/Downstream/79455;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/899729, chr7-CpG: 86/Downstream/231169
Nearby gene
IGFBP3(-900204) ; TNS3(+453677) ;
Nearest cancer related gene
IGFBP3(TSG, -900204) ;
Upstream sequence
AAAATAGACATATGAAAATTTAAAAAAGAAAAGGTCCTGATGAGGAGGCTCCTATCAGAAAGTGACATTTACCTAAACCCTCTTATATaacaacaacaac
Downstream sequence
ctcctgaaggaagagctaaacatggaaaggaacaaccggtaccagccgctgcaaaatcatgccaaaatgtaaagaccatcgagactaggaagaaactgca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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