Basic Information
VIS ID
TVIS10014605
Fusion event
HBV-chr16 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1808
Orient
-
Integrated sequence
TTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCAC| |CAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGAC
Host Sequence
Chromosome
chr16
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
51320025/51286114 (Hg38)
End
51320025/51286114 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1225/Upstream/543737; hsa-mir-11401/Downstream/4959406;
Nearest TSS
ENST00000527434/Upstream/39259; ENST00000642667/Downstream/70418;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/129765, chr16-CpG: 125/Downstream/1259610
Nearby gene
SALL1(-134842) ; C16orf97(+740239) ;
Upstream sequence
ATATTATGGGCTGATCTTGAAGGCTTGATTGACCAAGGCTGATTGTGTGCCAAAATAACGCGTTTCTCCTCCTTCGGTACCTGGGAAAGACATCCCACTT
Downstream sequence
TGCGAACCCCACTAAATAAGAATTTTCTTTCTGCTGGACTATGACTGGTGATGTGCTGTGACTCTTTGGTAATCATCCTTAGTGGGATCAGTTGGGGCTA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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