VISDB Viral Integration Site DataBase

VIS ID

TVIS10014644

Fusion event

HBV-TERT integration

Validated

No

Detection method

WGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1783

Orient

+

Integrated sequence

CAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTG| |TAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCC

Chromosome

chr5

Cytoband

p15.33

Reference genome

Start

End

1296404/1296289 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-138-5p ; hsa-mir-498 ; hsa-mir-193b-3p ; hsa-mir-335-5p ; hsa-mir-512-5p ; hsa-mir-1207-5p ; hsa-mir-1266-5p ; hsa-mir-1182 ; hsa-mir-181a-5p ; hsa-mir-6776-3p ; hsa-mir-197-3p ; hsa-mir-6740-3p ; hsa-mir-6760-3p ; hsa-mir-532-5p ; hsa-mir-3064-5p ; hsa-mir-422a ; hsa-mir-346 ; hsa-mir-1226-3p ; hsa-mir-1255a ; hsa-mir-1255b-5p ; hsa-mir-143-3p ; hsa-mir-3161 ; hsa-mir-3605-5p ; hsa-mir-3620-3p ; hsa-mir-3682-3p ; hsa-mir-4323 ; hsa-mir-4712-3p ; hsa-mir-4733-3p ; hsa-mir-4758-3p ; hsa-mir-4770 ; hsa-mir-6088 ; hsa-mir-7112-3p

Nearest miRNA

hsa-mir-4635/Upstream/233315; hsa-mir-10397/Downstream/13021;

Nearest TSS

Nearest CpG islands

None/Target, chr5-CpG: 87/Upstream/434, chr5-CpG: 18/Downstream/38673

Nearest cancer related gene

TERT(OG, No orient, 0)

Upstream sequence

gcagaaacatgcacacacgacgcagaaacgcgcacgcgcgcatacacgacgcagaaacgcacgcgcgcacacgacgcagaaacgcgcacacgtgcacaca

Downstream sequence

GCATTTGAACAGGCCTCGCACCCTCCCTGGGCTGTCACGCTCGCTGGAGGTTAGCCTCGTCTTGTAAATACTTAGGATTACAGGTCGCTCTTCTAGAAAT