TCL1A _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10014653
Fusion event
HBV-TCL1A integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27064257
Virus Sequence
Virus name
HBV
Reference genome
AF533983.1
Start
1805
Orient
+
Integrated sequence
CTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAATGATCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCA| |CCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGA
Host Sequence
Chromosome
chr14
Cytoband
q32.13
Reference genome
GRCh37/hg19
Start
96181078/95714741 (Hg38)
End
96181078/95714741 (Hg38)
Orient
+
Location type
Intronic
Target gene
TCL1A
miRNAs that regulate target gene
hsa-mir-29b-3p ; hsa-mir-181b-5p
Nearest miRNA
hsa-mir-1260a/Upstream/576755; hsa-mir-1185-1/Downstream/4394678;
Nearest TSS
ENST00000550708/Upstream/545; ENST00000556386/Downstream/739;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/230, chr14-CpG: 151/Downstream/161131
Nearest cancer related gene
TCL1A(OG, No orient, 0)
Upstream sequence
TGGATCTCCACCAGCCTGTGCCTTTGAGTGTCAGAGTACGTTTTTTGGCAAAGGACAACTCCTGACGCTCCCTCTCCCTCTTCCATACACAAAGCATGCG
Downstream sequence
TTTTCCACAGGTCTGATGTGCTGTGGACATCTAATAGCTATTACAAAATGGAGAATCATGGGTTTTTGCCCTTGGGCTTTGAGTTTACTAGTGAAAGCAT
Reference
Fujimoto, A., et al. Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer. Nat Genet ,2016,48(5): 500-509.
Curate