Basic Information
VIS ID
TVIS10014674
Fusion event
HBV-ADAM5 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27064257
Virus Sequence
Virus name
HBV
Reference genome
AB033550.1
Start
1771
Orient
+
Integrated sequence
TCTCATCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGT| |ACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCT
Host Sequence
Chromosome
chr8
Cytoband
p11.22
Reference genome
GRCh37/hg19
Start
39200454/39342935 (Hg38)
End
39200454/39342935 (Hg38)
Orient
-
Location type
Intronic
Target gene
ADAM5
Nearest miRNA
hsa-mir-124-1/Upstream/9385587; hsa-mir-10400/Downstream/1928113;
Nearest TSS
ENST00000518652/Upstream/72059; ENST00000520001/Downstream/241554;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/235031, chr8-CpG: 30/Downstream/179771
Upstream sequence
CAATACCACCTCTTTATTTTGAAACAAACATTAACCAATGCACAGTAAATTACCAATGCACAGTAAATTAGGAAATAAATATGATAGTAAAGCAATCATA
Downstream sequence
tgaaaataaaaTTTTtaagagttaaaatgctttgatacctgcatttaaaactggcattgtacaatataaagataaatggtaaaattcatgctaataactt
Reference
Fujimoto, A., et al. Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer. Nat Genet ,2016,48(5): 500-509.
Curate