VISDB Viral Integration Site DataBase

VIS ID

TVIS10014702

Fusion event

HBV-XRCC5 integration

Validated

No

Detection method

WGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

743

Orient

+

Integrated sequence

GAGTGGGCCTCAGTCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGA| |TGATGTGGTATTGGGGGCCAAGTCTGTACAACATCTTGAGTCCCTTTTTACCTCTATTACCAATTTTCTTTTGTCTTTGGGTATACATTTGAACCCTAAT

Chromosome

chr2

Cytoband

q35

Reference genome

Start

End

217055411/216190688 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-484 ; hsa-mir-331-3p ; hsa-mir-7-5p ; hsa-mir-100-5p ; hsa-mir-26b-5p ; hsa-mir-7977 ; hsa-mir-4528 ; hsa-mir-584-5p ; hsa-mir-758-5p ; hsa-mir-218-2-3p ; hsa-mir-29b-1-5p ; hsa-mir-361-5p ; hsa-mir-92a-2-5p ; hsa-mir-3927-5p ; hsa-mir-4726-3p ; hsa-mir-6764-5p ; hsa-mir-1915-3p ; hsa-mir-6840-3p ; hsa-mir-1324 ; hsa-mir-2115-3p ; hsa-mir-31-5p ; hsa-mir-526b-5p ; hsa-mir-623

Nearest miRNA

hsa-mir-10b/Upstream/2432529; hsa-mir-1244-1/Downstream/1709825;

Nearest TSS

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/81147, chr2-CpG: 85/Downstream/180614

Nearest cancer related gene

XRCC5(TSG, No orient, 0)

Upstream sequence

CCTTTGCTTTCTGTTCCTATTTAGGGAACCAAGGAAATTTCCATTATAACCTCTGGTGGCCCACTCACTATTGTAAAGGATGGGCTATTTTAGGGAAATG

Downstream sequence

GATGGGAAATATATATTGGTATAATTATTGAGAAAGATTTTATGAAGACAGGAGTAGGGATCTAAATGTCAGAAAAAAAAGAACACTGACAATAAGTTCC