ADAMTS6 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10014714
Fusion event
HBV-ADAMTS6 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27064257
Virus Sequence
Virus name
HBV
Reference genome
AP011098.1
Start
2754
Orient
+
Integrated sequence
CCTAACCTTACCAAATATTTGCCCTTGGATAAAGGCATTAAACCTTATTATCCTGAACATGCAGTTAATCATTACTTCAAAACTAGGCATTATTTACATA| |CTCTGTGGAAGGCTGGCATTCTATATAAGAGAGAAACTACACGCAGCGCTTCATTTTGTGGGTCACCATATTCTTGGGAACAAGAGCTACAGCATGGGAG
Host Sequence
Chromosome
chr5
Cytoband
q12.3
Reference genome
GRCh37/hg19
Start
64503439/65207612 (Hg38)
End
64503439/65207612 (Hg38)
Orient
-
Location type
Intronic
Target gene
ADAMTS6
miRNAs that regulate target gene
hsa-mir-148b-3p ; hsa-mir-221-3p
Nearest miRNA
hsa-mir-10397/Upstream/5503909; hsa-mir-103a-1/Downstream/6961855;
Nearest TSS
ENST00000502646/Upstream/8847; ENST00000508982/Downstream/6571;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/104223, chr5-CpG: 43/Downstream/355336
Upstream sequence
acagtgcctcacacagtataggtgctcaatgagtatttgatgaataaatCTCTACTTCCTACATAATAACCAGTCTGGTCATACCGATAGACTTTATACA
Downstream sequence
GTAGGGTAGAAAATTATCATGAATATTGCTGCATTCTGCAAAGATTCATTCTCTTAAAGAAAGTAACTTCCTAAAAAATGAAGGTCTTCTCTGATTAGAA
Reference
Fujimoto, A., et al. Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer. Nat Genet ,2016,48(5): 500-509.
Curate