VISDB Viral Integration Site DataBase

VIS ID

TVIS10014729

Fusion event

HBV-POLA2 integration

Validated

No

Detection method

WGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1839

Orient

-

Integrated sequence

TTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAAT| |CATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGCTTCTGTG

Chromosome

chr11

Cytoband

q13.1

Reference genome

Start

End

65023717/65256246 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-1-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-7977 ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-383-3p ; hsa-mir-1265 ; hsa-mir-2392 ; hsa-mir-5684 ; hsa-mir-3149 ; hsa-mir-297 ; hsa-mir-675-3p ; hsa-mir-1185-2-3p ; hsa-mir-1185-1-3p ; hsa-let-7f-2-3p ; hsa-mir-4789-5p ; hsa-mir-98-3p ; hsa-let-7f-1-3p ; hsa-let-7b-3p ; hsa-let-7a-3p ; hsa-mir-145-3p ; hsa-mir-3171 ; hsa-mir-3605-5p ; hsa-mir-4729 ; hsa-mir-4666a-3p ; hsa-mir-381-3p ; hsa-mir-300 ; hsa-mir-6862-5p ; hsa-mir-4253 ; hsa-mir-3945 ; hsa-mir-3622b-5p ; hsa-mir-7703 ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-4252 ; hsa-mir-4793-3p ; hsa-mir-766-3p ; hsa-mir-1292-3p ; hsa-mir-6849-3p ; hsa-mir-1273g-3p ; hsa-mir-3940-3p ; hsa-mir-508-5p ; hsa-mir-4439 ; hsa-mir-3136-5p ; hsa-mir-5001-3p ; hsa-mir-6820-3p ; hsa-mir-3118 ; hsa-mir-134-5p ; hsa-mir-5581-5p ; hsa-mir-4297 ; hsa-mir-6857-3p ; hsa-mir-4513 ; hsa-mir-6855-3p ; hsa-mir-3117-5p ; hsa-mir-6730-3p ; hsa-mir-942-5p ; hsa-mir-199b-5p ; hsa-mir-199a-5p ; hsa-mir-4302 ; hsa-mir-888-3p

Nearest miRNA

hsa-mir-10392/Upstream/126268; hsa-let-7a-2/Downstream/188212;

Nearest TSS

Nearest CpG islands

None/Target, chr11-CpG: 30/Upstream/30233, chr11-CpG: 81/Downstream/5323

Upstream sequence

ATTTTCTTTCTTTCTTTCCTTTTCTTTTCTttctttctttttttttttttttttttttttgagatggagtcttgctgtgtcacccaggccagagtgcaat

Downstream sequence

ggtgcaatcttggctcactgcaacctccacctcccaggttcaagcgattctccccagcctcagcctcctgagtagctgggattacaggcgactgccactg