VISDB Viral Integration Site DataBase

VIS ID

TVIS10014731

Fusion event

HBV-SEMA6B integration

Validated

No

Detection method

WGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

2446

Orient

+

Integrated sequence

TAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAA| |TGTTAGTATCCCTTGGACTCATAAGGTGGGAAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTGAGTGGCAAACTCCCTCCTTTCCT

Chromosome

chr19

Cytoband

p13.3

Reference genome

Start

End

4558119/4558107 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-19b-3p ; hsa-mir-7702 ; hsa-mir-4524b-3p ; hsa-mir-129-2-3p ; hsa-mir-129-1-3p ; hsa-mir-1227-5p ; hsa-mir-1229-3p ; hsa-mir-128-1-5p ; hsa-mir-128-2-5p ; hsa-mir-197-3p ; hsa-mir-3199 ; hsa-mir-3620-3p ; hsa-mir-3622b-5p ; hsa-mir-365a-5p ; hsa-mir-365b-5p ; hsa-mir-4292 ; hsa-mir-4699-3p ; hsa-mir-504-5p ; hsa-mir-6511a-3p ; hsa-mir-6511b-3p ; hsa-mir-6762-5p ; hsa-mir-6784-3p ; hsa-mir-6791-5p ; hsa-mir-6845-5p ; hsa-mir-6852-5p ; hsa-mir-6862-3p ; hsa-mir-7110-3p ; hsa-mir-8052 ; hsa-mir-92b-5p

Nearest miRNA

hsa-mir-1227/Upstream/112059; hsa-let-7e/Downstream/212563;

Nearest TSS

Nearest CpG islands

None/Target, chr19-CpG: 112/Upstream/1976, chr19-CpG: 24/Downstream/244

Upstream sequence

tgctgtcccCAGCAATACCTGTCCCCAATGAACAGCGTCCTGTTGACCCGCAGGACTCGCTGGATGTTGAGGTCGTCAGCACCTTCTGCGGGGGTCAGGC

Downstream sequence

GTCCGGGCCCGCTGCCCACAAACACGGGATAGTGGTTCAGGTCTGAGTGAGGGGGTGGAGAGGGGTGTGAGCAAGGGCTGGGGGTGAAGAGAGGGTGGCC