VISDB Viral Integration Site DataBase

VIS ID

TVIS10014735

Fusion event

HBV-EML4 integration

Validated

No

Detection method

WGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1822

Orient

+

Integrated sequence

TTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTT| |TTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAG

Chromosome

chr2

Cytoband

p21

Reference genome

Start

End

42456683/42229543 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-1-3p ; hsa-mir-30b-5p ; hsa-mir-16-5p ; hsa-mir-877-3p ; hsa-mir-652-3p ; hsa-mir-148b-3p ; hsa-mir-651-3p ; hsa-mir-551b-5p ; hsa-mir-548c-3p ; hsa-let-7f-2-3p ; hsa-mir-30a-5p ; hsa-mir-30c-5p ; hsa-mir-30d-5p ; hsa-mir-30e-5p ; hsa-mir-1185-2-3p ; hsa-mir-1185-1-3p ; hsa-mir-142-3p ; hsa-mir-552-5p ; hsa-mir-302c-5p ; hsa-mir-5683 ; hsa-mir-212-3p ; hsa-mir-132-3p ; hsa-mir-107 ; hsa-mir-103a-3p ; hsa-mir-548o-3p ; hsa-mir-1323 ; hsa-mir-587 ; hsa-mir-377-3p ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485

Nearest miRNA

hsa-mir-1301/Upstream/6758057; hsa-mir-10b/Downstream/5148132;

Nearest TSS

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/59750, chr2-CpG: 61/Downstream/131389

Nearest cancer related gene

EML4(OG, No orient, 0)

Upstream sequence

CTTACACATGAACTTTGTATTCCAGGAACAGTTATGTTAGTAAAATATTAAATGGTAGAGAATTTTTTCATAAAGCAAGACAGATAACTGTCTTGCAAGA

Downstream sequence

GTCACCCATTCACCACGAGAGAGAAAAATAAAAGAAATGTGAGTGAGTGAGTTTAGGGCTAAATACATGTAAATACTGAGTTTGTCAGAGGAATCAGGGA