Basic Information
VIS ID
TVIS10014746
Fusion event
HBV-FYB2 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27064257
Virus Sequence
Virus name
HBV
Reference genome
AP011098.1
Start
1451
Orient
+
Integrated sequence
CTCGGAAATACACCTCCTTCCCATGGCTGCTCGGGTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTCTACGTCCCGTCGGCGCTGAATCCCGC| |GGACGACCCGTCTCGGGGCCGTTTGGGGCTCTACCGTCCCCTTCTTCATCTGCCGTTCCGGCCGACCACGGGGCGCACCTCTCTTTACGCGGTCTCCCCG
Host Sequence
Chromosome
chr1
Cytoband
p32.2
Reference genome
GRCh37/hg19
Start
57257046/56791373 (Hg38)
End
57257046/56791373 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1B
Target gene
FYB2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-148b-3p
Nearest miRNA
hsa-mir-12136/Upstream/1565650; hsa-mir-101-1/Downstream/2941854;
Nearest TSS
ENST00000473358/Upstream/29360; ENST00000361249/Downstream/27998;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/145809, chr1-CpG: 222/Downstream/630918
Upstream sequence
tagacaggatcttgctctgttgcccaggctggagtgaagtggtacaattttggctcactacaacctctgcctcccaggttcaagcaattcttgtgtctca
Downstream sequence
gcttcccgagtagctgggattacaggcacaggccaccatgtccagctaatttttgtatttttaatagagatggggttttgccatattagccaggctggtt
Reference
Fujimoto, A., et al. Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer. Nat Genet ,2016,48(5): 500-509.
Curate