VISDB Viral Integration Site DataBase

VIS ID

TVIS10014779

Fusion event

HBV-PRKN integration

Validated

No

Detection method

WGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1855

Orient

-

Integrated sequence

GGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGT| |CCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGCTTCTGTGGAGTTACTCTCTTTTT

Chromosome

chr6

Cytoband

q26

Reference genome

Start

End

162294328/161873296 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-26b-5p ; hsa-mir-3187-3p ; hsa-mir-1303 ; hsa-mir-4435 ; hsa-mir-588 ; hsa-mir-4701-5p ; hsa-mir-548s ; hsa-mir-193b-5p ; hsa-mir-4755-3p ; hsa-mir-483-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-181a-5p

Nearest miRNA

hsa-mir-10398/Upstream/3108543; hsa-mir-1913/Downstream/4636058;

Nearest TSS

Nearest CpG islands

None/Target, chr6-CpG: 120/Upstream/226639, chr6-CpG: 75/Downstream/854048

Nearest cancer related gene

PRKN(TSG, No orient, 0)

Upstream sequence

gtggtatttacactcagacatgtagtacatttttttttttctggcaggtagttaggttgaatcaatctagtaagtagttgagctagatttggagtgtatt

Downstream sequence

TCGCTCCATGTTTGGAACATGCTTACTCTGAAGTTAGATATCCTGGGGCATAAGTTATACTGTGGCGTGTTTGGAAACTATGCAAGCATGAAATATACAC