Basic Information
VIS ID
TVIS10014788
Fusion event
HBV-FRG1-DT integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27064257
Virus Sequence
Virus name
HBV
Reference genome
AP011098.1
Start
822
Orient
+
Integrated sequence
TTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAACATCTTGAGTCCCTTTTTACCTCTATTACCAATTTTCTTTTGTCTTTG| |GGTATACATTTGAACCCTAATAAAACCAAACGTTGGGGCTACTCCCTTAACTTCATGGGATATGTAATTGGAAGTTGGGGTACTTTACCACAGGAACATA
Host Sequence
Chromosome
chr4
Cytoband
q35.2
Reference genome
GRCh37/hg19
Start
190730779/189809625 (Hg38)
End
190730779/189809625 (Hg38)
Orient
-
Location type
Intronic
Target gene
FRG1-DT
Nearest miRNA
hsa-mir-12113/Upstream/4871185;
Nearest TSS
ENST00000502981/Upstream/105135; ENST00000503609/Downstream/71890;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/163057, chr4-CpG: 66/Downstream/867
Upstream sequence
ttcctctttggttgtctattttTAAATGAAAAAGCACCAGGATTTTAGAAATATCTTTTTTTTTGGTCAATCATATATGACCCAAATCAATATGACCAAA
Downstream sequence
ATACATTTTTTTCACATTAAGCCACTGAAGAAAAAAAATACCACAGGAAATTAACAATTTTCAAAACTGTTCTTTTACCTAAAGCTCTTTTCATATCTTC
Reference
Fujimoto, A., et al. Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer. Nat Genet ,2016,48(5): 500-509.
Curate