Basic Information
VIS ID
TVIS10014802
Fusion event
HBV-chr21 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27064257
Virus Sequence
Virus name
HBV
Reference genome
AP011098.1
Start
2922
Orient
+
Integrated sequence
TATTCTTGGGAACAAGAGCTACAGCATGGGAGGTTGGTCTTCCAAACCTCGACAAGGCATGGGGACGAATCTTTCTGTTCCCAATCCTCTGGGATTCTTT| |CCCGATCACCAGTTGGACCCTGCGTTCGGAGCCAACTCAAACAATCCAGATTGGGACTTCAACCCCAACAAGGATCACTGGCCAGAGGCAAATCAGGTAG
Host Sequence
Chromosome
chr21
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
47547287/46127373 (Hg38)
End
47547287/46127373 (Hg38)
Orient
-
Location type
Intronic
Target gene
COL6A2 ; LOC100288508
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-10b-5p ; hsa-mir-10a-5p ; hsa-mir-3928-3p ; hsa-mir-29c-3p
Nearest miRNA
hsa-let-7c/Upstream/649047;
Nearest TSS
ENST00000624081/Upstream/6813; ENST00000446649/Downstream/9961;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/1075, chr21-CpG: 40/Downstream/1651
Upstream sequence
AAACCTCAGGGTCTGCGGTACGAAGTCAGCGCTTCCTCAGCACGCGGGTCGCGGTGTGCGTTCGGGCGTTCCATGGGGAGCTCCCGGTGGGTGAGCTGGG
Downstream sequence
CCACTGAGCACATTCACAGGCCCTGAGGCTGCCCCAGGGGAGGAGCCGTGGACTCAGAGCCGAGGTTCCCCATACGTGCTGCGACAGAGAACCTAGGGCT
Reference
Fujimoto, A., et al. Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer. Nat Genet ,2016,48(5): 500-509.
Curate