VISDB Viral Integration Site DataBase

VIS ID

TVIS10014810

Fusion event

HBV-chr6 integration

Validated

No

Detection method

WGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1744

Orient

+

Integrated sequence

AGGTCTTACATAAGAGGACTCTTGGACTCTCATCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGG| |GGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCT

Chromosome

chr6

Cytoband

p21.1

Reference genome

Start

End

44270937/44303200 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

AARS2 ; TCTE1

miRNAs that regulate target gene

hsa-mir-484 ; hsa-mir-378a-5p ; hsa-mir-23b-3p ; hsa-mir-92a-3p ; hsa-mir-574-5p ; hsa-mir-6867-5p ; hsa-mir-3650 ; hsa-mir-4455 ; hsa-mir-6804-5p ; hsa-mir-4789-5p ; hsa-mir-3941 ; hsa-mir-1284 ; hsa-mir-6865-3p ; hsa-mir-1228-3p ; hsa-mir-603 ; hsa-mir-8485 ; hsa-mir-329-3p ; hsa-mir-362-3p ; hsa-mir-342-3p ; hsa-mir-4709-3p ; hsa-mir-4699-5p ; hsa-mir-4474-3p

Nearest miRNA

hsa-mir-10398/Upstream/48915; hsa-mir-10524/Downstream/132441;

Nearest TSS

Nearest CpG islands

None/Target, chr6-CpG: 120/Upstream/5226, chr6-CpG: 40/Downstream/9782

Upstream sequence

CTGAACTCACTGTAGGACACACTTTGTGGATTTATTGTGTGTTTTGAAGTCACACTGTGAGCTATATAGAATTAACCAAAACACAACTCTTCTTGAAAAT

Downstream sequence

TTAACTGCCAAAGGAGAAGGATAAAGCCTCCAGGTATGCCTGAAGGAGGCCCCCGATCTCCAGCAAAAGGGCTTCCCCAACTCACCTCATCCAGAGAGCG