VISDB Viral Integration Site DataBase

VIS ID

TVIS10014811

Fusion event

HBV-chr6 integration

Validated

No

Detection method

WGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1834

Orient

-

Integrated sequence

AGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGC| |CTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGCTT

Chromosome

chr6

Cytoband

p21.1

Reference genome

Start

End

44270941/44303204 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

AARS2 ; TCTE1

miRNAs that regulate target gene

hsa-mir-484 ; hsa-mir-378a-5p ; hsa-mir-23b-3p ; hsa-mir-92a-3p ; hsa-mir-574-5p ; hsa-mir-6867-5p ; hsa-mir-3650 ; hsa-mir-4455 ; hsa-mir-6804-5p ; hsa-mir-4789-5p ; hsa-mir-3941 ; hsa-mir-1284 ; hsa-mir-6865-3p ; hsa-mir-1228-3p ; hsa-mir-603 ; hsa-mir-8485 ; hsa-mir-329-3p ; hsa-mir-362-3p ; hsa-mir-342-3p ; hsa-mir-4709-3p ; hsa-mir-4699-5p ; hsa-mir-4474-3p

Nearest miRNA

hsa-mir-10398/Upstream/48919; hsa-mir-10524/Downstream/132437;

Nearest TSS

Nearest CpG islands

None/Target, chr6-CpG: 120/Upstream/5230, chr6-CpG: 40/Downstream/9778

Upstream sequence

tgactctgtgacttgctacgtatcctagaataaattccctttctgcttaaactacttggaggtggttGCAGGGGTGGTAGTTCAGCAGCTGGGCTGGTAG

Downstream sequence

CTGCCAAAGGAGAAGGATAAAGCCTCCAGGTATGCCTGAAGGAGGCCCCCGATCTCCAGCAAAAGGGCTTCCCCAACTCACCTCATCCAGAGAGCGCAGG