VISDB Viral Integration Site DataBase

VIS ID

TVIS10014837

Fusion event

AAV2-CCNE1 integration

Validated

No

Detection method

WGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

AAV2

Reference genome

Start

4600

Orient

+

Integrated sequence

GATAAGTAGCATGGCGGGTTAATCATTAACTACAAGGAACCCCTAGTGATGGAGTTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGC| |GACCAAAGGTCGCCCGACGCCCGGGCTTTGCCCGGGCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAA

Chromosome

chr19

Cytoband

q12

Reference genome

Start

End

30304511/29813604 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-15b-5p ; hsa-mir-503-5p ; hsa-mir-424-5p ; hsa-mir-16-5p ; hsa-mir-15a-5p ; hsa-mir-107 ; hsa-mir-185-5p ; hsa-mir-103a-3p ; hsa-mir-26b-5p ; hsa-mir-26a-5p ; hsa-mir-16-1-3p ; hsa-mir-195-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-151a-3p ; hsa-mir-342-5p ; hsa-mir-125b-5p ; hsa-mir-92a-3p ; hsa-mir-383-3p ; hsa-mir-497-5p ; hsa-mir-4524a-5p ; hsa-mir-4694-3p ; hsa-mir-4524b-5p ; hsa-mir-6838-5p ; hsa-mir-7-5p ; hsa-mir-4477a ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-5191 ; hsa-mir-646 ; hsa-mir-25-5p ; hsa-mir-30c-2-3p ; hsa-mir-144-5p ; hsa-mir-892b

Nearest miRNA

hsa-mir-10395/Upstream/9414250; hsa-let-7e/Downstream/5309096;

Nearest TSS

Nearest CpG islands

None/Target, chr19-CpG: 112/Upstream/830, chr19-CpG: 21/Downstream/29929

Nearest cancer related gene

CCNE1(OG, No orient, 0)

Upstream sequence

TTTAAGGACCTCCTCCGTCTTCTGTAGGTCAGATTTCAAATTCTTCTCCTCTTTCTGGCCCTGGAAGTTCTTATAGCCCCTCCAGCAATTACCTGCATTG

Downstream sequence

ATCCCCAGCTCAGCCTGACCTCAGCAAGAGTATCAGTGGAACATTCAGTGTAATGATAGGTGGTGTCTCAATACATTTTTTTTTGACTGCTTTTCTTTTC