Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10014842
Fusion event
HBV-MECOM integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Start
193
Integrated sequence
TCCGACTACTGCCTCACCCATATCGTCAATCTTCTCGAGGACTGGGGACCCTGCACAGAACATGGAGAGCACAACATCAGGATTCCTAGGACCCCTGCTC| |GTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCACAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAGCACCCA
Host Sequence
Chromosome
chr3
Cytoband
q26.2
Reference genome
End
169023909/169306121 (Hg38)
Location type
Intronic
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-let-7g/Upstream/754172; hsa-mir-1224/Downstream/1116982;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/156496, chr3-CpG: 122/Downstream/355528
Nearest cancer related gene
MECOM(OG, No orient, 0)
Upstream sequence
cctgtaatcccagcactttctgaggccgaggcgggcggatcacaaggtcaggagatcaagaccaccctggctaacacggtgaaaccccTCGATGATAGTT
Downstream sequence
TCATGCACAGGTGTTTAAAGTAAAGCATTATCGAGGTAATAAAAAATTCATGATTATCTTCCTTTGTATAATTATAGCTGAATATTATGCAATAAGTTCA
Reference
Fujimoto, A., et al. Whole-genome mutational landscape of liver cancers displaying biliary phenotype reveals hepatitis impact and molecular diversity. Nat Commun ,2015,6: 6120.