Basic Information
VIS ID
TVIS10014858
Fusion event
HBV-MEF2C-AS1 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634756
Virus Sequence
Virus name
HBV
Reference genome
NC_003977.1
Start
687
Integrated sequence
GAAACTGCACTTGTATTCCCATCCCATCATCCTGGGCTTTCGCAAGATTCCTATGGGAGTGGGCCTCAGTCCGTTTCTCCTGGCTCAGTTTACTAGTGCC| |ATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGCTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAACATCTTGAGTCCC
Host Sequence
Chromosome
chr5
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
88754909/89459092 (Hg38)
End
88754909/89459092 (Hg38)
Location type
Intronic
Target gene
MEF2C-AS1
Nearest miRNA
hsa-mir-10397/Upstream/792153; hsa-mir-103a-1/Downstream/557529;
Nearest TSS
ENST00000502646/Upstream/40285; ENST00000503691/Downstream/10947;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/569320, chr5-CpG: 17/Downstream/950434
Upstream sequence
CGGGGAGCGCGCGGCATCGCGGGGGTGGCCGGGGCCAGGGCTTCCCACGTGCGCAGCAGGACGCAGCGCTGCCTGAAACTCGCGCCGCGAGGAGAgggcg
Downstream sequence
AATAGGTTTGTGATATTTTCAGTTCTGATTTTTAATATTTATTGCAATATGTTTTGTAAAATTCTAAAAATAAAGATAGATGAATTACCTACTGTAAGAT
Reference
Fujimoto, A., et al. Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators. Nat Genet,2012, 44(7): 760-764.
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