VISDB Viral Integration Site DataBase

VIS ID

TVIS10014859

Fusion event

HBV-TERT integration

Validated

Yes

Detection method

PCR and Sanger sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2012

PubMed ID

Virus name

HBV

Reference genome

Start

1783

Integrated sequence

CAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTG| |TAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCCCCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCC

Chromosome

chr5

Cytoband

p15.33

Reference genome

Start

End

1275381/1275266 (Hg38)

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-138-5p ; hsa-mir-498 ; hsa-mir-193b-3p ; hsa-mir-335-5p ; hsa-mir-512-5p ; hsa-mir-1207-5p ; hsa-mir-1266-5p ; hsa-mir-1182 ; hsa-mir-181a-5p ; hsa-mir-6776-3p ; hsa-mir-197-3p ; hsa-mir-6740-3p ; hsa-mir-6760-3p ; hsa-mir-532-5p ; hsa-mir-3064-5p ; hsa-mir-422a ; hsa-mir-346 ; hsa-mir-1226-3p ; hsa-mir-1255a ; hsa-mir-1255b-5p ; hsa-mir-143-3p ; hsa-mir-3161 ; hsa-mir-3605-5p ; hsa-mir-3620-3p ; hsa-mir-3682-3p ; hsa-mir-4323 ; hsa-mir-4712-3p ; hsa-mir-4733-3p ; hsa-mir-4758-3p ; hsa-mir-4770 ; hsa-mir-6088 ; hsa-mir-7112-3p

Nearest miRNA

hsa-mir-4635/Upstream/212292; hsa-mir-10397/Downstream/34044;

Nearest TSS

Nearest CpG islands

None/Target, chr5-CpG: 87/Upstream/1880, chr5-CpG: 18/Downstream/2086

Nearest cancer related gene

TERT(OG, No orient, 0)

Upstream sequence

ttgctcccacaagtaagggagaacatgaaaagtttgtctttctgtgcctggcttatttcacttaacatactgaccagtgccccccatgctgttgcaactg

Downstream sequence

gggaggctgaggcaagagaattgcttgaactcaggaagcacaggttgcagtgagccaagatcacgccaaaccactccagcctgggcaaaaaagagcgaga