Basic Information
VIS ID
TVIS10014863
Fusion event
HBV-ADAM5 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634756
Virus Sequence
Virus name
HBV
Reference genome
NC_003977.1
Start
1771
Integrated sequence
TCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGT| |ACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCCCCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCT
Host Sequence
Chromosome
chr8
Cytoband
p11.22
Reference genome
GRCh37/hg19
Start
39200450/39342931 (Hg38)
End
39200450/39342931 (Hg38)
Location type
Intronic
Target gene
ADAM5
Nearest miRNA
hsa-mir-124-1/Upstream/9385583; hsa-mir-10400/Downstream/1928117;
Nearest TSS
ENST00000518652/Upstream/72055; ENST00000520001/Downstream/241558;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/235027, chr8-CpG: 30/Downstream/179775
Upstream sequence
TAACAGTTGGAGACACTGGCTTCTGGAAAAACATTTATCTTTTTTTGGATTCACTCTTCCCACTTTGCTGGTCACAATGCAATATTTCATTATATTCTTG
Downstream sequence
caactgaaaataaaaTTTTtaagagttaaaatgctttgatacctgcatttaaaactggcattgtacaatataaagataaatggtaaaattcatgctaata
Reference
Fujimoto, A., et al. Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators. Nat Genet,2012, 44(7): 760-764.
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